● TIER 1 — FDA-approved / recognizedGRADE AReproductive hormones
hCG
Gonadotropin. Research verification: Yes (TGA pending). 1 human study record(s) in the FitClinicMD studies database.
GOALS · Hormone optimization / menopause / low T · Sexual function
FDA status
Approved (Novarel, Pregnyl) for hypogonadotropic hypogonadism, ovulation induction; not for weight loss (label disclaimer).
Compounding (503A/503B)
Biologic since Mar 23 2020 BPCI Act transition — NOT eligible for 503A/503B compounding (only mixing/diluting/repackaging of approved product per 2018 guidance)
DEA
Not controlled federally.
WADA (sport)
S2.2.1 Testosterone-stimulating peptides in males (CG, LH, GnRH/gonadorelin & agonist analogues, kisspeptin & agonist analogues)
Mechanism
LH-receptor agonist.
Human evidence · 1
Review: TRT and spermatogenesis (hCG for preservation). Testosterone replacement therapy and spermatogenesis in reproductive age men.
Reference only. This page summarizes publicly available regulatory and research information about hCG. It is not a prescription, an endorsement, or an offer to dispense, and regulatory status can change. Clinicians should verify current status before prescribing or compounding.
Related compounds
● TIER 1GRADE A
Gonadorelin & GnRH analogs
GnRH agonists (leuprolide, triptorelin, goserelin) cause downregulation; antagonists (degarelix, relugolix, elagolix) block directly.
● TIER 2GRADE B
Anastrozole & other AIs
Block aromatase.
● TIER 2GRADE B
Clomiphene / Enclomiphene
Hypothalamic ER antagonism ↑LH/FSH.